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8, 0. 6) and SD (5 mm, 7 mm, 9 mm). Representation of women in N-TA 3 CT is important even though there is not enough power to analyze data separately for women. Abdominal aortic aneurysm is not as well studied in women as in men, and we believe that information will be valuable. HMG-CoA reductase inhibitors (statins) were being taken by 163 (82%). Discussion N-TA 3 CT is a Phase IIb clinical trial because the primary outcome is a continuous, anatomical measurement that patients do not perceive, instead of a clinical event important to patients (i. . repair, rupture, death) that would be required for a Phase III clinical trial. We are gaining information about the distribution, growth and correlations of CT scan measurements of AAA maximum transverse diameter, adherence to study treatment, adverse effects of study treatment, retention and completeness of follow-up that will be necessary for a Phase III clinical trial. N-TA 3 CT is designed as a critical experiment that will determine whether doxycycline can reduce MMP-9 levels and reduce systemic markers of inflammation (interferon- gamma and hs-CRP) in ways that we associate in bench experiments and observational human studies with AAA growth. We will learn whether or not we are pursuing a pathogenesis that applies in humans and whether we are pursuing an efficacious or an inefficacious treatment. If doxycycline has an effect of marginal clinical relevance, the search for more potent or specific MMP inhibitors could be the next step. Even if doxycycline has no effect on aneurysm growth, we will be assaying specimens for candidate biomarkers and banking specimens for possible assay of new biomarker candidates that could be surrogates for expansion. Based on the present state of knowledge, a hypothesis that inflammation results in AAA growth and elevates MMP-9 and hs-CRP levels as systemic markers of this inflammation is plausible. Under this scenario, we hypothesize doxycycline will produce a series of events: 1) therapeutic levels of doxycycline are achieved in the aneurysm; 2) a reduction of MMP-9 levels is observed; 3) a reduction in hs-CRP is observed; 4) a reduction in aneurysm expansion is observed.

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He made sure that the victory was a fair one in terms of game regulations (rules which have a penalty or consequence during the game) but had to stoop down to a level which has marred his image to quite an extent in the heart of many of his fans. So what we are left with is an example of when breaking the rules is morally acceptable. Maradona used his hand, in clear violation of basic football rules, but he wasn’t punished for it. His goal was counted, the win stood as it is, and there were no further ramifications. While some people were clearly upset, it isn’t all that clear whether the English fans were more upset over losing because of the illegal goal or that they actually rejected Maradona’s rule-breaking goal on “principle”. Rather, his goal is more often met with general amusement, sly smiles, and blame on the referees for not calling it- not on the player for trying it. CASE TWO: A broken rule resulting in punishment In a match against Italy during the 2014 World Cup, Uruguayan striker Luis Suarez appeared to have bitten Italian defender Giorgio Chiellini. This type of violent action against an opposing player is clearly against the rules- it’s prohibited, just as the use of a hand is. Yet, this act caused a sturdier reaction in response. The act is condemned and despised, and Suarez was, after the game was over and the incident reviewed, suspended from “all football-related activity” for four months, as well as had to pay a fine for the incident. This action was strictly met with punishment- not amusement. Suarez’s action crossed some unspoken ethical1 line. Perhaps the line is injury; doing something that would cause physical harm to an opponent is considered unethical. CASE THREE: A broken rule which resulted in a punishment but stirred the world with mixed reactions The stage was finally set. Africans around the world and those who had taken on the Black Stars as their second team were cheering on the men in red.

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Honestly, though, what other possible reason could there have been to include those two scenes, if not to set up a future scene in which Arya confronts Sandor and reconciles her conflicting emotions. There will be a emotional reunion between those two at the very least. The Hound is going to be pretty shocked to see how much Sansa has changed and Arya will be shocked to see how the Hound has “mellowed” in his old age lol. Too much of an age difference between the actors (in the books Sandor is probably in his late 20s), and a different sort of relationship (thankfully) put onscreen. The point is, the scenes didn’t really work on a dramatic and narrative level because they were trying to do too much at once. Ultimately it is believable that Bran has changed profoundly, but not believable that he is devoid of all emotion. He needed more to work with to show a believability to what he now is and isn’t. Always fancied Sandor and Brienne, but the girl has way too many suitors now. It must have been common knowledge that Robert Baratheon was killed by a boar in a hunting accident. Even the actors in Braavos included that in their road show. So perhaps Gendry in his mind had decided long ago that the Lannisters were also behind the death of his father. When she admitted to various things such as an incestuous relationship with her brother, but firstly admitting she had killed her husband. I would be 100% cool with her choosing never to marry again personally. The original plan was to have 7 seasons of 10 episodes. However the 7th season had too much information to cover and was extended to 13 episodes which was divided into two seasons due to the cgi.

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